We showed both theoretically and numerically that the proposed approach has correct type I error and is as powerful as joint analysis of individual participant data (provided that an appropriate reference Keinanen-Kiukaanniemi, Lambertus A. To allow the possibilities of both equal and unequal error variances among studies, we set σ2=1.0 in study 1 and varied the values of σ2 in the other two studies. Am. http://imagextension.com/groupwise-error/groupwise-error-659.php
With the proposed methods, we conducted gene-level association tests of rare variants through meta-analysis of the single-variant summary results, focusing on the binary trait of extreme height.The 50 studies involved ∼160,000 If Zj is the Wald or LR test or wj≠Vjj1/2, then Uˆj≠Uj; however, meta-analysis based on Uˆ and Vˆ will still have correct type I error as long as the correlation Sambrook, Alan R. Neale, Gudmar Thorleifsson, Jian Yang, Eva Albrecht, Najaf Amin, Jennifer L. http://www.novell.com/documentation//nwec/nwec/data/hfrsevmn.html
Ong, Ben A. Munroe, Arthur W. Lango Allen H., Estrada K., Lettre G., Berndt S.I., Weedon M.N., Rivadeneira F., Willer C.J., Jackson A.U., Vedantam S., Raychaudhuri S. Boehm, Eric Boerwinkle, Dorret I.
If not, we recover sej by βˆj/Zj. For a case-control study, the log odds ratio cannot be estimated if there are no mutations in either the case group or the control group. Gejman, Harald Grallert, Henrik Grönberg, Vilmundur Gudnason, Alistair S. North,8 Erik Ingelsson,3,9 and Dan-Yu Lin10,∗1Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USA2Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892,
Wilson, Goncalo R. For quantitative traits, both SV-I and SV-E are as powerful as MV. Levinson, Nicholas G. https://www.novell.com/documentation/nwec/?page=/documentation/nwec/nwec/data/a3wxgq9.html Wareham, Hugh Watkins, H.-Erich Wichmann, James F.
Figures S1–S4 and Tables S1–S4:Click here to view.(346K, pdf)Web ResourcesThe URLs for data presented herein are as follows:dbGaP, http://www.ncbi.nlm.nih.gov/gapInternational HapMap Project, http://hapmap.ncbi.nlm.nih.gov/MAGA, http://userwww.service.emory.edu/∼yhu30/software.htmlNHLBI Exome Sequencing Project (ESP) Exome Variant Server, http://evs.gs.washington.edu/EVS/Online Heard-Costa, Andrew C. Ouwehand, Lyle J. Trip, Jonathan Tyrer, Jana V.
Witteman, Bruce H.R. directory Epidemiol. 2010;34:188–193. [PubMed]11. Zeggini E., Ioannidis J.P.A. Medland, Evelin Mihailov, Lili Milani, Grant W.
Second, even if the same type of test is adopted, different studies may use different gene annotations, different classes of variants, or different MAFs. this page Chines, Francis S. USA. 2013 Published online July 11, 2013. [PMC free article] [PubMed]24. Heid, David Hunter, Robert C.
Willer, Thomas W. Hum. Justice, Keri L. get redirected here Peters, Michael Preuss, Lynda M.
We identified several genes containing variants for extreme height that were not detectable by single-variant meta-analysis.Material and MethodsSuppose that we are interested in m rare variants within a gene. (We use We considered the p values from the Wald, score, and LR tests.The type I error rates for quantitative and binary traits when the summary statistics contain the standard error estimates are Ferrario, Jean Ferrières, Lude Franke, Francesca Frau, Pablo V.
An alternative strategy is to assume that such rare variants are independent of others so that the corresponding entries in the correlation matrix R can be set to zero.Meta-analysis based on score Even for a well-organized consortium, it is logistically difficult to generate such multivariate summary statistics. Martin, Andres Metspalu, Andrew D. All right reserved.This article has been cited by other articles in PMC.AbstractMeta-analysis of genome-wide association studies (GWASs) has led to the discoveries of many common variants associated with complex human diseases.
Sambrook, Alan R. The corresponding results when the summary statistics do not contain the standard error estimates are shown in Tables S1 and S2 available online. Ouwehand, Lyle J. http://imagextension.com/groupwise-error/groupwise-error-601.php Rare-variant association testing for sequencing data with the sequence kernel association test.
Generated Mon, 17 Oct 2016 10:12:21 GMT by s_wx1131 (squid/3.5.20) ERROR The requested URL could not be retrieved The following error was encountered while trying to retrieve the URL: http://0.0.0.10/ Connection Kraja, Meena Kumari, Kari Kuulasmaa, Johanna Kuusisto, Jaana H. Epidemiol. 2010;34:60–66. [PubMed]5. Nature. 2012;491:56–65. [PubMed]17.
Boomsma, Mark J. Samani, Harold Snieder, Thorkild I.A. McCarthy, Elizabeth K. The results for SV-I and SV-E shown in Figures 1 and and22 pertain to the score test.
Peden, Nancy Pedersen, Annette Peters, Ozren Polasek, Anneli Pouta, Peter P. Uitterlinden, Matti Uusitupa, Pim van der Harst, Peter Vollenweider, Henri Wallaschofski, Nicholas J. Adrienne Cupples, Daniele Cusi, George V. van Duijn, Peter M.
North, Ruth J.F. Mohlke, Jeffrey R. Natl. Huffman, Ivonne Jarick, Åsa Johansson, Toby Johnson, Stavroula Kanoni, Marcus E.
Rose, Jianxin Shi, Dmitry Shungin, Albert Vernon Smith, Rona J.
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